Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases
  • 49
  • 119 948
Anifrolumab modulates key immune pathways in patients with systemic lupus erythematosus (SLE)
To cite: Baker T, Sharifian H, Newcombe PJ, et al. Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials. Annals of the Rheumatic Diseases Published Online First: 03 April 2024. doi: 10.1136/ard-2023-225445
Read the full article here: dx.doi.org/10.1136/ard-2023-225445
Introduction: Anifrolumab is a type I interferon (IFN) receptor 1 (IFNAR1) blocking antibody approved for treating patients with systemic lupus erythematosus (SLE). Here, we investigated the immunomodulatory mechanisms of anifrolumab using longitudinal transcriptomic and proteomic analyses of the 52-week, randomised, phase 3 TULIP-1 and TULIP-2 trials.
Discussion: Type I IFN blockade with anifrolumab modulated multiple inflammatory pathways downstream of type I IFN signalling, including apoptotic, innate and adaptive mechanisms that play key roles in SLE immunopathogenesis.
Переглядів: 191

Відео

CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis
Переглядів 5475 місяців тому
To cite: Papadimitriou TI, Singh P, van Caam A, et al. CD7 activation regulates cytotoxicity-driven pathology in systemic sclerosis, yielding a target for selective cell depletion. Annals of the Rheumatic Diseases Published Online First: 18 December 2023. doi: 10.1136/ard-2023-224827 Read the full article here: dx.doi.org/10.1136/ard-2023-224827 Objective: Cytotoxic T cells and natural killer (...
Bimekizumab treatment in patients with active axial spondyloarthritis: results up to week 52
Переглядів 1437 місяців тому
To cite: Baraliakos X, Deodhar A, van der Heijde D, et al. Bimekizumab treatment in patients with active axial spondyloarthritis: 52-week efficacy and safety from the randomised parallel phase 3 BE MOBILE 1 and BE MOBILE 2 studies. Annals of the Rheumatic Diseases Published Online First: 04 October 2023. doi: 10.1136/ard-2023-224803 Read the full article here: dx.doi.org/10.1136/ard-2023-224803...
Bimekizumab 52-week efficacy and safety in biologic DMARD-naïve patients with active PsA
Переглядів 1839 місяців тому
To cite: Ritchlin CT, Coates LC, McInnes IB, et al. Bimekizumab treatment in biologic DMARD-naïve patients with active psoriatic arthritis: 52-week efficacy and safety results from the phase III, randomised, placebo-controlled, active reference BE OPTIMAL study. Annals of the Rheumatic Diseases Published Online First: 11 September 2023. doi: 10.1136/ard-2023-224431 Read the full article here: d...
EULAR recommendations for the non-pharmacological management of lupus and scleroderma
Переглядів 2049 місяців тому
To cite: Parodis I, Girard-Guyonvarc’h C, Arnaud L, et al. EULAR recommendations for the non-pharmacological management of systemic lupus erythematosus and systemic sclerosis. Annals of the Rheumatic Diseases Published Online First: 10 July 2023. doi: 10.1136/ard-2023-224416 Read the full article here: dx.doi.org/10.1136/ard-2023-224416 Objective: To develop evidence-based recommendations for t...
Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors
Переглядів 107Рік тому
To cite: Kristensen LE, Danese S, Yndestad A, et al. Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors: an analysis of the open label, randomised controlled study ORAL Surveillance. Annals of the Rheumatic Diseases Published Online First: 17 March 2023. doi: 10.1136/ard-2022-223715 Read the full article here: dx.doi.org/10.1136/ard-2022-223715 O...
Long-term persistence and effectiveness of IL-12/23 pathway inhibitor ustekinumab and TNF inhibitors
Переглядів 149Рік тому
To cite: Gossec L, Siebert S, Bergmans P, et al. Long-term effectiveness and persistence of ustekinumab and TNF inhibitors in patients with psoriatic arthritis: final 3-year results from the PsABio real-world study. Annals of the Rheumatic Diseases Published Online First: 13 December 2022. doi: 10.1136/ard-2022-222879 Read the full article here: dx.doi.org/10.1136/ard-2022-222879 Objective: To ...
Recapture and retreatment rates with ixekizumab after withdrawal of therapy in patients with axSpA
Переглядів 119Рік тому
To cite: Landewé RBM, Poddubnyy D, Rahman P, et al. Recapture and retreatment rates with ixekizumab after withdrawal of therapy in patients with axial spondyloarthritis: results at week 104 from a randomised placebo-controlled withdrawal study. Annals of the Rheumatic Diseases Published Online First: 13 September 2022. doi: 10.1136/ard-2022-222731 Read the full article here: dx.doi.org/10.1136/...
ORAL Surveillance trial: risk of cardiovascular events with tofacitinib vs TNFi in patients with RA
Переглядів 615Рік тому
To cite: Charles-Schoeman C, Buch MH, Dougados M, et al. Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of atherosclerotic cardiovascular disease: a post hoc analysis from ORAL Surveillance. Annals of the Rheumatic Diseases Published Online First: 22 September 2022. doi: 10.113...
Olokizumab combined with methotrexate in patients with rheumatoid arthritis
Переглядів 280Рік тому
To cite: Feist E, Fatenejad S, Grishin S, et al. Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study. Annals of the Rheumatic Diseases Published Online First: 15 September 2022. doi...
ROSAH syndrome is an autoinflammatory disease: Drs. Christina Kozycki and Dan Kastner, NIH
Переглядів 1,2 тис.Рік тому
To cite: Kozycki CT, Kodati S, Huryn L Undiagnosed Diseases Network, et al. Gain-of-function mutations in ALPK1 cause an NF-κB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome. Annals of the Rheumatic Diseases Published Online First: 22 July 2022. doi: 10.1136/annrheumdis-2022-222629 Read the full article here: dx....
Concordance and discordance in SLE clinical trial outcome measures
Переглядів 6852 роки тому
To cite: Bruce IN, Furie RA, Morand EF, et alConcordance and discordance in SLE clinical trial outcome measures: analysis of three anifrolumab phase 2/3 trialsAnnals of the Rheumatic Diseases Published Online First: 17 May 2022. doi: 10.1136/annrheumdis-2021-221847. Read the full article here: dx.doi.org/10.1136/annrheumdis-2021-221847 Objective: In the anifrolumab systemic lupus erythematosus ...
Anifrolumab efficacy and safety by type I IFNGS and clinical subgroups in patients with SLE
Переглядів 5472 роки тому
To cite: Vital EM, Merrill JT, Morand EF, et al. Ann Rheum Dis. doi: 10.1136/annrheumdis-2021-221425 Read the full article here: dx.doi.org/10.1136/annrheumdis-2021-221425 Objective: To characterise the efficacy and safety of anifrolumab in patients with systemic lupus erythematosus (SLE) according to interferon gene signature (IFNGS), demographic and clinical subgroups. Conclusions: Overall, t...
Meet the new Editor in Chief of ARD, Josef Smolen
Переглядів 2342 роки тому
The most successful journal in the field of rheumatology, the present and the future. Professor Josef Smolen (University of Vienna, Austria) introduces his ideas for Annals of the Rheumatic Diseases, as he takes over as the editor-in-chief. ARD, the official journal of EULAR, covers all aspects of rheumatology from the spectrum of musculoskeletal conditions to arthritic disease and connective t...
Persistence and effectiveness of the IL-12/23 pathway inhibitor ustekinumab
Переглядів 1942 роки тому
To cite: Gossec L, Siebert S, Bergmans P, et al. Ann Rheum Dis. doi: 10.1136/annrheumdis-2021-221640. Read the full article here: dx.doi.org/10.1136/annrheumdis-2021-221640 Objective: We evaluated real-world treatment persistence and effectiveness at 1 year following initiation of IL-12/23 inhibitor ustekinumab or a tumour necrosis factor inhibitor (TNFi) for psoriatic arthritis (PsA). Conclusi...
Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, trial in psoriatic arthritis
Переглядів 1,5 тис.2 роки тому
Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, trial in psoriatic arthritis
Phase II Randomisedrandomised Trialtrial of Typetype I IIA
Переглядів 2022 роки тому
Phase II Randomisedrandomised Trialtrial of Typetype I IIA
Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells
Переглядів 1392 роки тому
Blocking GM-CSF receptor α with mavrilimumab reduces infiltrating cells
Efficacy and safety of guselkumab in patients with active psoriatic arthritis
Переглядів 1,1 тис.2 роки тому
Efficacy and safety of guselkumab in patients with active psoriatic arthritis
Efficacy and safety results of a randomised controlled phase III study
Переглядів 1682 роки тому
Efficacy and safety results of a randomised controlled phase III study
Secukinumab in patients with psoriatic arthritis and axial manifestations
Переглядів 1,5 тис.3 роки тому
Secukinumab in patients with psoriatic arthritis and axial manifestations
Revisiting the use of remission criteria for RA by excluding patient global assessment
Переглядів 2533 роки тому
Revisiting the use of remission criteria for RA by excluding patient global assessment
BBB leakage in SLE is associated with gray matter loss and cognitive impairment
Переглядів 3823 роки тому
BBB leakage in SLE is associated with gray matter loss and cognitive impairment
Infections in baricitinib clinical trials for patients with active rheumatoid arthritis
Переглядів 7033 роки тому
Infections in baricitinib clinical trials for patients with active rheumatoid arthritis
Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis
Переглядів 5073 роки тому
Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis
Safety and tolerability of nintedanib in patients with interstitial lung disease
Переглядів 3393 роки тому
Safety and tolerability of nintedanib in patients with interstitial lung disease
Historically controlled comparison of glucocorticoids: results of the CHIC study
Переглядів 793 роки тому
Historically controlled comparison of glucocorticoids: results of the CHIC study
Maintenance of Clinical Remission in Early Axial Spondyloarthritis
Переглядів 1864 роки тому
Maintenance of Clinical Remission in Early Axial Spondyloarthritis
Altered cognitive function in systemic lupus erythematosus
Переглядів 17 тис.4 роки тому
Altered cognitive function in systemic lupus erythematosus
Novel ultrasonographic Halo Score for giant cell arteritis
Переглядів 7 тис.4 роки тому
Novel ultrasonographic Halo Score for giant cell arteritis

КОМЕНТАРІ

  • @martinfricek4787
    @martinfricek4787 Місяць тому

    Please, may I have the name of the radiologist?

  • @juliepatel8947
    @juliepatel8947 2 місяці тому

    Very informative

  • @MzGumby02
    @MzGumby02 7 місяців тому

    There are days where I feel like I have amnesia or have had a stroke.

  • @amerebumpintheroad
    @amerebumpintheroad 7 місяців тому

    Extreme flares can lead to confusion, misinterpretation of everything and personality changes and irrational reactions due to confusion and inability to be in reality

  • @ghostmantagshome-er6pb
    @ghostmantagshome-er6pb 8 місяців тому

    That was fascinating.

  • @pjperalta
    @pjperalta 9 місяців тому

    Scientists have found the relationship of transgenic wheat (gluten) to people becoming stupid and sick - See the article published by PubMed - Gluten induced neurocognitive impairement (Brain Fog Lupus) www.ncbi.nlm.nih.gov/pmc/articles/PMC9256899/ They have been killing people for decades with transgenic wheat (gluten) and glyphosate. See the articles published for about 15 years by Dr. Stephanie Seneff and her team in the MIT.

  • @moniquehvshogendoornvs2348
    @moniquehvshogendoornvs2348 10 місяців тому

    Was the MRI taken with or without contrast medium?

  • @Hvamp
    @Hvamp Рік тому

    I have SLE and over the last several days I have had dizzy spells, a feeling that I’m drugged, flush face, tingling on face etc. Last night I was laughing and got very dizzy like I was going to pass out. Afterwards I could not get my 13 year old daughter birthday right. I was completely convinced the wrong date was right. She kept saying no mom. After 20 minutes I knew her birthday again just like I always have. It made me nervous and scared as to how I could have gotten it wrong and be so convencer that the wrong date was right. Should I go for a brain scan. I know lupus can attack the brain and I’m concerned. It’s been effecting my vision too while I’m walking.

  • @music..languageofthesoul.124

    M suffering from RA ...please give other option than methatraxate

  • @Ben_Mdws
    @Ben_Mdws Рік тому

    1:19 - if you want the name of it said out loud.

  • @carlosalbertoloaizacardena8044

    Thank you for sharing

  • @rebrichards9228
    @rebrichards9228 Рік тому

    Do you read private scans you seem to go in depth very well I'm. It Happy with my scan reader it's very basic

  • @DungeonMaster07
    @DungeonMaster07 Рік тому

    can it be taken for lifetime?

  • @omhenryom
    @omhenryom Рік тому

    My Rheumatologist hasn't gotten the memo. Could you send it to her?

  • @joyallen4513
    @joyallen4513 Рік тому

    Hello everyone, I am here with joy in my heart to thank Dr. EHBOS on UA-cam, an herbalist from Africa for permanently curing me of Hsv1 and 2, thank you doctor and God bless you

  • @yakubuyakubu509
    @yakubuyakubu509 Рік тому

    Helping me get rid of my Lupus infection is what I will never forget in my whole life #drogoh. You're welcome to my family, thanks for saving my life .💛

  • @ashleygary1724
    @ashleygary1724 Рік тому

    I’m so excited to be cured! I’m glad I found you here on UA-cam Doc Kham.

    • @Jadae
      @Jadae 11 місяців тому

      There is no such thing as a Lupus cure. Only therapeutic intervention via lifestyle changes and medications.

  • @ashleygary1724
    @ashleygary1724 Рік тому

    I’m so excited to be cured! I’m glad I found you here on UA-cam Doc Kham. Curing me from herpes is something I never imagined.

  • @Bubblesandcandyfloss
    @Bubblesandcandyfloss 2 роки тому

    Low vitamin D is common with lupus. Particularly if you’re sensitive to the sun. I have SLE. trying to bring up my vit d. It’s helped a bit.

  • @elvinashourn4673
    @elvinashourn4673 2 роки тому

    I’m very excited that I’m totally cured of my HPV virus 🦠 of 3 year’s of diagnosed and there’s no medication that was to help me get it permanently till i was introduced to an Africa herbal doctor Oare who cured me permanently and symptoms anymore again after series’s of test done ✅ thank you very much dr OARE ON UA-cam ,

  • @dannyomon8786
    @dannyomon8786 2 роки тому

    Though I haven't met with Dr Ben Uda on UA-cam, I have being hearing and seeing his wonderful deed on people's life.. This made me contacted him because I was also diagnosed of HPV, When I contacted Him, without wasting time, he started His Miraculous work in my Life, I am so happy and glad to say that I am now cured completely after using His herbal medicine.

  • @petrprecious4345
    @petrprecious4345 2 роки тому

    his herbal medication is 100% Cure for Shingles virus and any disease virus and STDs I was cured after 12days of using the herbal medicine I ordered from Dr.Ani John contact him now and get your permanent cure...

  • @antoniojames3798
    @antoniojames3798 2 роки тому

    l,m forever grateful to a man called DR.Osaka on UA-cam channel who recommended his herbal medicine for me and i got completely cured of Lupus, may God bless you sir.

  • @dprince5271
    @dprince5271 2 роки тому

    Being diagnosed with Lupus has been a major loss of money and has caused major problems in my immune system,but when I came across Dr. Osaka on UA-cam Channel and he recommended his herbal medicine I got completely cured of Lupus?

  • @user-ey4rh5sf2s
    @user-ey4rh5sf2s 2 роки тому

    🍀🍀🍀

  • @simonpreciousjoyce2386
    @simonpreciousjoyce2386 2 роки тому

    Testifying about Dr Ogie Herbal on UA-cam is the great joy I have ever had in a while because, this man transformed my life In all ramification. Thanks doctor for putting an end to my lupus and putting a smile on my face again Thanks doc 🤗

  • @janeclark832
    @janeclark832 2 роки тому

    Thank you Dr. ONO for using your good herbal medication to get rid of my Lupus permanently.

  • @VictorVMiles
    @VictorVMiles 2 роки тому

    I got rid of my Lupus permanently with the natural herbs of DR ONO on UA-cam contact him if you are also infected

  • @scarlettfreedom3629
    @scarlettfreedom3629 2 роки тому

    🩹✌🏻❤️

  • @aminualiyu8948
    @aminualiyu8948 2 роки тому

    After a life time of diagnosed with lupus I got cured with the help of Dr imenherbal on UA-cam channel and till now I'm free from lupus. ua-cam.com/channels/1PVLGWeT3a6Cto-kOD9IfQ.html

  • @michealdorcas877
    @michealdorcas877 2 роки тому

    Dr Susan Oduwa is a God sent. if you don't believe in herbs I guess this is the best time to reach out to #DrSusanOduwa because she helped me got rid of herpes virus and I am 💯 cured.

  • @preciouseguasa9519
    @preciouseguasa9519 2 роки тому

    I am so grateful to dr osazee on UA-cam who cured me from hsv_2 with his effective herbal medicine may God bless you sir you are truly a man of your world

  • @preciouseguasa9519
    @preciouseguasa9519 2 роки тому

    I am so grateful to dr osazee on UA-cam who cured me from hsv_2 with his effective herbal medicine may God bless you sir you are truly a man of your world

  • @rebrichards9228
    @rebrichards9228 2 роки тому

    Who do you see for a specialist for SI joint pain. Anyone get buttock pain near medius gluteal and near hip?

    • @Mckenna12502
      @Mckenna12502 3 місяці тому

      A orthopedic Doctor you need an m.R.I and yextreme pain in your buttocks the back of the thigh It's the worst pain imaginable but you wanna start with a MRI at a Orthopedic Doctor. I have it on my right side. Possibly both I need AC. T next, I wish you the best of luck.

  • @lisaeaster4665
    @lisaeaster4665 2 роки тому

    I recommend Dr.Auchi on UA-cam channel for saving my life from Sle Lupus disease 🦠, when I use the herbal remedies I get from Dr.Auchi. I was totally 💯 cured completely..ua-cam.com/channels/6tA16t1IlKx1bY93lc2rcg.html ✅

  • @annierobin9158
    @annierobin9158 2 роки тому

    I still can't believe it's happening ,that I would be 100% free from lupus well all thanks to dr osuma on UA-cam ..it's a miracle !

  • @BUTTALUV
    @BUTTALUV 2 роки тому

    I’m on my 2nd month of Taltz with Methotrexate which I’ve been on for 2 years. I had some progress with Humira. But after the Covid injections it stopped working. I’m looking for answers and support for PsA without psoriasis.

    • @lanchicoolidge1888
      @lanchicoolidge1888 2 роки тому

      Hi Butta Luv, i have been using Otezla 30mg tablets for Psoriasis and PsA and psoriasis is under control very good. I’m still looking for the biologic med to help to control the inflammation stronger like Taltz … Before covid I used to get Cimzia and Leflunomide which sent me to TB. But anyway those duo didn’t help much. And now while I’m using Otezla Dr gives me Xeljanz pills but searching for the side effects shows its horrible 😬

  • @t.a.g.thealgorithmgenerato2395
    @t.a.g.thealgorithmgenerato2395 2 роки тому

    Grab a speaker and let the vibration target the lupus condition. ua-cam.com/video/5UoFzK387i4/v-deo.html

  • @francisdave5020
    @francisdave5020 2 роки тому

    I was cured of herpes simplex virus 1 & 2 by a great herbal doctor called Dr olotu with the use of different combination of Africa herbs. it is still like a dream to me. There is no word suitable enough to qualify your significant in my life dear doctor Olotu.

  • @ismailmusa633
    @ismailmusa633 2 роки тому

    Do you know there are root and herbs which can eliminate Autoimmune, Scleroderma and Lupus Symptoms slowly in 2 weeks Roots and plants like; Anise , aralia,basil chamomile with little seamoss and a lot others my dear, this my herbs cure are without no side effects at all. I came on UA-cam seeing others making comments in herbs and Dr Steven. Really his herbs are effective and natural 100%, I got it delivered to me and took it warm for 2 weeks , 2 times daily. The Symptoms slowly went away and a week after I got a negative results for both incurable diseases. Herbs is really good way of approaching a definite cure meet him here for more herbs Information ( orderherbs.steven@gmail.com )

  • @ezeriepromise9678
    @ezeriepromise9678 2 роки тому

    I was having Lupus and HPV warts which caused me pains. I had bad symptoms on my skin due to the condition and I have been diagnosed since 2016. I saw Dr. Steven page here and I laser for his herbs because he has many recommendations and has cured many people. I ordered the herbs and took it for 5 days. my symptoms gradually went of and few days ago my doctor here in Texas couldn’t trace my HPV and Lupus anymore. I want anyone who need help on their health should contact Dr Steven because he cured many and others thanks. (+2348163807836). ( orderherbs.steven@gmail.com ).

  • @chooseaname1423
    @chooseaname1423 3 роки тому

    I recently got a hold of my rheumatologists old notes and he wrote "MRI of pelvis showed fat replacement on SI joint." He never told me this and I cannot see him for another 3 months. Can anyone explain what this could mean? My MRI never had a note like this from a radiologist. I did have a CT of my pelvis where the radiologist noted a “rounded dystrophic calcification measuring 5mm adjacent to inner aspect of the left pubic symphysis of uncertain clinical significance" and my doctor had no idea what that was or what to do about it. Could these two notes be about the same thing?

  • @trentgay3437
    @trentgay3437 3 роки тому

    diagnosed with psoriatic arthritis 38, problems started at 15. I have si pain, planter facilities/enthesitis, neck pain, painful joints "ankle knee wrist elbow shoulder and fingers" and extreme fatigue. Almost all symptoms became manageable after first 5 week loading doses. After 2 months 150mg dose wearing off at two weeks. On 300mg now. Doesn't help my fatigue but great medicine for me highly recommended it if you have psoriatic arthritis.

  • @tucanal1992
    @tucanal1992 3 роки тому

    I got a cure for PSORIASIS and HPV. MY WARTS died off and now negative. I got treatment with herbs using Dr Steven Herbs. Get order from him orderherbs.steven@gmail.com

  • @MzClementine
    @MzClementine 3 роки тому

    Thank you so very much. From the bottom of my heart thank you.

  • @psoriaticarthritis-psa
    @psoriaticarthritis-psa 3 роки тому

    I’ve just started this, I just ca it TALTZ haha, my initial dose where I injected 2 x 80mg, within days my psoriasis on my scalp had calmed down which I’m super glad about. I inject every 2 weeks now for 12 week (I’m on week 4) but what he doesn’t tell you in this is that it stings really bad but I’m persevering because if it can clear my psoriasis up (which other meds haven’t) then hopefully it will work on my joints & when I get to doing it just once every 4 week it will be easier.

  • @danieljames9861
    @danieljames9861 3 роки тому

    I was referred to Dr. Osade on UA-cam who genuinely helped me defeat Lupus completely.

    • @jasoncollins7677
      @jasoncollins7677 2 роки тому

      I have to call you a liar! I have lupus (it's terrible), I looked at this Dr. Osade's UA-cam page and found nothing but videos on herpes! Hope he helped you defeat your herpes! If you knew how terrible an illness lupus was- you would not be spreading disinformation about treating it. Please don't spread your herpes the way you spread disinformation!

    • @lisaeaster4665
      @lisaeaster4665 2 роки тому

      I recommend Dr.Auchi on UA-cam channel for saving my life from Sle Lupus disease 🦠, when I use the herbal remedies I get from Dr.Auchi. I was totally 💯 cured completely..ua-cam.com/channels/6tA16t1IlKx1bY93lc2rcg.html ✅

  • @cleanprofessionals
    @cleanprofessionals 3 роки тому

    are you able to advise some imagery for me if sent across for a second opinion

  • @longhaired93
    @longhaired93 3 роки тому

    I just had some done will you read mine plzzzzzzzzzzzzz😊

    • @longhaired93
      @longhaired93 3 роки тому

      also, is there contrast used in these exams?

  • @thYrd3Y3prYing
    @thYrd3Y3prYing 3 роки тому

    I feel enlightened by my newfound knowledge of the pronunciation of Ixekizumab and all subsequent information imparted herein. Very well done.